Data from the Metropolitan Police showed 22 domestic homicides in 2020, up from 16 in 2019.
The 2020 figure includes 12 children, compared with seven in 2019.
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All the child deaths are under review by the force and other support services.
Commander Dave McLaren said: “It is fair to say that mental health has played a part in a number of those crimes this year and it isn’t a massive leap of faith to say that lockdown has an impact on all of us in terms of our wellbeing.
“In terms of those cases, we have to see those reviews through and better understand the circumstances surrounding each of them before we get to the point of concluding that there’s a direct correlation with the lockdown.”
Domestic tragedies in the capital in 2020 included the deaths of 19-month-old Pavinya Nithiyakumar and her brother, Nigish, 3, killed by their shop worker father Nadarajah Nithiyakumar while his wife was in the shower at their East London home in April, as reported by MyLondon.
In separate cases, Sutha Sivanantham, 36, from Mitcham, was charged with murdering her five-year-old daughter, Sayagi Sivanantham, at their home in June, and Mariam Benzain, 32, of Preston Road, Harrow, is accused of killing her five-month-old son, Elias Biad, in July.
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Another case involved the deaths of three-year-old Kailash Kuha Raj and his 36-year-old mother, Poorna Kaameshwari Sivaraj, who it is believed were murdered by father and husband Kuha Raj Sithamparanathan, 42, in October.
He stabbed himself to death when police arrived at the family home in Brentford on October 6.
Senior Met officers say it is unclear why the total number of homicides did not drop further despite the capital being in lockdown for significant parts of the year.
In 2020 the borough with the most domestic homicides was Redbridge with 3, despite not recording any the year before.
Below is a map of London plotting where domestic homicides took place in 2020 compared to 2019 according to Metropolitan Police data:
Number of Domestic homicides in 2020 compared to (2019) in each borough
Barking and Dagenham: 1 (1)
Barnet: 0 (2)
Bexley: 1 (0)
Brent: 1 (1)
Bromley: 0 (0)
Camden: 0 (0)
Croydon: 1 (1)
Ealing: 2 (0)
Enfield: 2 (1)
Greenwich: 2 (0)
Hackney: 2 (0)
Hammersmith & Fulham: 1 (0)
Haringey: 0 (0)
Harrow: 0 (0)
Havering: 0 (1)
Hillingdon: 0 (0)
Hounslow: 1 (0)
Islington: 0 (0)
Kensington & Chelsea: 0 (2)
Kingston upon Thames: 1 (0)
Lambeth: 1 (0)
Lewisham: 1 (0)
Merton: 0 (0)
Newham: 0 (0)
Redbridge: 3 (0)
Richmond upon Thames: 0 (2)
Southwark: 1 (2)
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Sutton: 0 (0)
Tower Hamlets: 1 (3)
Waltham Forest: 2 (0)
Wandsworth: 0 (0)
Westminster: 0 (0)